As you can tell from Buzz above, the pricing is not totally out of line. Cigarettes in Florida are heavily taxed (I had a guest complain about almost $6.00 packs). I don't smoke, so I wouldn't know except for a complain. Alcohol is not overly taxed; but each state seems to be different. OTC medicines are in small brand name packets and consequently pricey (unless you need them).
In other words, if you can bring it from home, do so. If you can't, Panchito's is like a small convenience store not like Target or Walmart and pricing is similar.